Expression of Cyclooxygenase Enzymes in the Eye of Dogs
نویسندگان
چکیده
The aim of the present study was to measure mRNA levels of cyclooxygenase-1 (COX1), cyclooxygenase-2 (COX2) and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFIkBα) in eye tissues of dogs by real time polymerase chain reaction (RT-PCR). These factors are involved in the maintenance of homeostasis and in inflammation. Additionally, they are target for anti-inflammatory drugs. Six dogs from different breeds and without ocular diseases were included in the study. COX1, COX2 and NFIkBα mRNA were found in the conjunctiva, the cornea and the retina. Expression of mRNA levels of COX1, COX2 and NFIkBα suggest a constitutive expression and indicate a role in canine ocular homeostasis. These data can be used in the light of proper management of inflammation in eye tissues as well as anti-inflammatory drug application.
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